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Abstract #3932

Quantitative Characterization of a Catalyzed PHIP Reaction

Shawn Wagner1, 2, Jose Agraz3, Debiao Li1, 2

1Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States; 2Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States; 3Bioengineering, UCLA, Los Angeles, CA, United States

Hyperpolarization by field cycling and RF transfer utilizing parahydrogen requires a fast addition of hydrogen to preserve the spin alignment of the parahydrogen. To effectively utilize PHIP to produce the highest hyperpolarization, characterization of the reaction kinetics is required. The purpose of this research is to demonstrate how to systematically characterize the reaction kinetics to calibrate and evaluate instrument performance using a common PHIP standard, 2-hydroxyethyl acrylate (HEA). We demonstrate for HEA, catalyst concentration has the greatest contribution to reaction rate.

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Keywords

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