Meeting Banner
Abstract #3931

Frequency Band-Selective Spiral CSI: Application to Imaging Cardiac Metabolism with Hyperpolarized [2-13C]pyruvate

Sonal Josan1, 2, Ralph Hurd3, Yi-Fen Yen2, Adolf Pfefferbaum1, 4, Daniel Spielman2, Dirk Mayer1, 2

1SRI International, Menlo Park, CA, United States; 2Radiology, Stanford University, Stanford, CA, United States; 3GE Healthcare; 4Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States

Spectroscopic imaging with hyperpolarized 13C substrates has been widely used to measure metabolic processes in real time in vivo. There has been growing interest recently in using hyperpolarized [2-13C]pyruvate, to follow the 13C label into metabolic products including glutamate (in exchange with α-ketoglutarate in the TCA cycle), citrate, acetyl-carnitine and acetoacetate as well as lactate and alanine. CSI with [2-13C]Pyr is challenging given the wide spectral dispersion of the resonances. This work uses a spectrally selective excitation to perform 3D CSI of spectral sub-bands containing metabolites of interest. Dynamic data is acquired from multiple sub-bands alternately in vivo in rat heart.

Abstract PDF Presentation Video

Keywords

abundance acquisitions activity administered alanine aliased allow allows alternately application approximately artifact assessment avoid band bands behavioral bicarbonate built cardiac challenging chemical citrate coil containing converts correction courses custom cycle dataset detection determines dirk dispersion displacement doublet downstream dynamic encoding entire every except excitation excitations excited fast field flux frequency glutamate gradient growing heart hence hereon implementation in vivo incorporation indicate indicates infusion injected injection insert instruments insufficient interleaving international label lactate limited linear located long magnitude maps mark measure metabolic metabolism metabolite midway natural nominal onto optimal organs oxford park particular passband pathways peak performance placed plot post prior processes products profile psychiatry pulse radiology rather rats readout real receive reduce releasing representative resolution respectively ripple ripples roll scanner sciences selective sensitivity separate severe slice solution spatially spectra spectral spectrally spectroscopic spectrum spiral started steps stimulate studies substrate successive suffers sufficient superimposed suppressed surface temporal though transmit volume volumetric wide widely width