Branched-Chain Amino Acid Metabolism in Prostate Cancer: Hyperpolarized [1-13C]-Ketoisocaproate as a Novel Molecular Probe

Keywords

accurate acid activity adapted addition address aggressive aggressiveness although amino animal another appear assay become biopsies body branched brooks cancer cause cell cells chain characterization clinical content controlled derived despite detected detection determine determined develop development dirk disease displayed distinctive distinguishes dual effort electrical elevated enter enzymatic examined experimentation extracts fast fiber flank forced form gram guiding health heart human in vivo induced injection instability international invasive kelvin kidney known leading lifetime liver mechanisms medium metabolic metabolism mice mirrored model models molecular monitored mouse negatives novel nude overall oxygen parental park penicillin performance plate poor possess powerful preparation previously probe product production prognostication progression prostate protein protocol pure radiology reaching recorded regression regulation relatively remains respect risk salt saturation scanner series side slow sodium software sources stage steady strategy studies subcutaneous suitable supplemented synthesis system tail temperature terms threshold tissue tool tramp treatment tumor tumors upon utilized utilizing validate various vitro volume weeks