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Abstract #3491

Improved IVIM Image Quantitation of Exercised Lower Back Muscles by Local Principle Component Analysis

Patrick Hiepe1, Daniel Gllmar2, Alexander Gussew3, Reinhard Rzanny2, Jrgen R. Reichenbach2

1Medical Physics Group, Institute of Diagnostic and Interventional Radiology I , Jena University Hospital, Jena, Germany; 2Medical Physics Group, Institute of Diagnostic and Interventional Radiology I, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany; 3Medical Physics Group, Institute of Diagnostic and Interventional Radiology I , Jena University Hospital - Friedrich Schiller University Jena , Jena, Germany

In this contribution the intra-voxel incoherent motion model (IVIM) imaging and local principle component analysis (LPCA) denoising was used to evaluate muscle fatigue by quantifying the load-induced perfusion changes in lower back muscles following exercise. LPCA decomposition was applied to improve image quality. Mapped diffusion coefficients (parameterized via D) and perfusion-related signal losses (parameterized via f) were used for ROI-based analyses. Mean D and f values revealed spatially varying increases post exercise which can thus be used for spatially resolved perfusion quantification as a physiological marker of muscle activity and fatigue during exercise.

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Keywords

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