Meeting Banner
Abstract #3490

MR Spectroscopy (MRS) in Objective Measurement of Intramuscular Fat as a Non-Invasive Biomarker: Comparison Study in Boys with Duchenne Muscular Dystrophy (DMD) and Healthy Boys.

Suraj D. Serai1, Hee Kyung Kim1, Paul Horn2, Brenda L. Wong2, Diana Lindquist1

1Radiology, CCHMC, Cincinnati, OH, United States; 2Neurology, CCHMC, Cincinnati, OH, United States

T1W imaging is not able to differentiate boys with DMD and minimal fatty infiltration from healthy boys. Most of the healthy boys and one-third of the boys with DMD demonstrated a minimal degree of fatty infiltration of the gluteus muscle. However using quantitative MRS, fatty infiltration measured by MRS is substantially higher in boys with DMD than in healthy boys. In fact, MRS can completely separate boys with DMD from healthy boys. Hence, we hypothesize that the advantage of using MRS over the traditional T1W imaging likely will be greater when applied to patients in the early stage disease.

Abstract PDF Presentation Video

Keywords

acquisition activity advantage aimed analyses applied approved approximately assess assessments biopsy body boys cardiac channel characterized chosen clinical coil conducted consistency correlation critically degree determine diagnosis differentiate disease disorders distribution done dystrophy early enabled fatal fatty function gives grade grading healthy height horn important index infiltration institute intramuscular invasive invasiveness involvement limited lipid maintained mapping mass matched material measure measures minimal minutes muscle muscles muscular neurology neuromuscular noninvasive objective pathologic pelvic plotted positioning practice prior progressive prospective quantify quantitative radiology recruited required response scanned scanner segregate separation shim significantly skeletal software spectroscopy statistical subjects suppression surface therapeutic torso utilized validate volume water whether years