Meeting Banner
Abstract #3492

Difussion Tensor Imaging Studies in Limb-Girdle Muscular Distrophies

Hidalgo-Tobon S. Silvia1, Gabriela R. Hernandez Salazar2, S Vargas-Caas2, O. Marrufo-Melendez3, S. Solis Najera4, Alfredo O. Rodriguez5, Rosa Delgado-Hernandez6

1Universidad Autonoma Metropolitana, Mexico City, Mexico, Mexico; 2Insituto Nacional de Neurologia, Mexico, Mexico; 3Insituto Nacional de Neurologia, DF, Mexico, Mexico; 4UNAM, MExico, Mexico; 5UAM, DF, Mexico, Mexico; 6Imagenologia, Instituto Nacional de Neurologia y Neurocirugia, DF, Mexico, Mexico

Limb-girdle muscular dystrophies (LGMD) are a group of autosomal dominantly or recessively inherited muscular dystrophies that also present with primary proximal (limb-girdle) muscle weakness. This type of dystrophy involves the shoulder and pelvic girdles, distinct phenotypic or clinical characteristics are recognized. LGM dystor-phies affect posterior thigh muscle compartment, predomi-nantly gracilis and sartorius muscles. In the thigh, muscles at the back are affected, with a tendency to preserve the tibi-alis anterior and gastrocnemius. In this study we analyze DTI images, relation between the number of tracts, FA, and lenght in sartorius and gracilis muscle.

Abstract PDF Presentation Video

Keywords

affect affected anisotropy anterior appear applied array assessed averaging back blue calculations channel characteristic characteristics characterize city clinical coefficients coil collinear combination compartment complete computed connective containing content controls correlation diffusion directionality distinct dominantly drawn dystrophy eigenvectors eight eleven examined fast fatty fiber fibers field fractional girdle girdles gradients green hand healthy infiltration inherited interpolated invasive involves limb loss magnet mass material matrix medical muscle muscles muscular negative nerve normalized parallel pathology patients pelvic position posterior predominantly preserve primary proximal qualitative quantitative recessively recognized relaxed repeated replacement resolution rheum sartorius scanned schematic secondary seventeen shoulder slice slices software spin statistics step streamline studies subject subjects supine systems table tendency tensor thigh thighs tissue tracking tract tracts type underlying unit utility volunteers weakness