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Abstract #3059

Reducing the Scan Time in Quantitative Dynamic Contrast Enhanced MRI of the Breast Using the Extended Graphical Model

Huijun Chen1, Matthew L. Olson2, Savannah C. Partridge3, William Kerwin3

1Tsinghua University, Beijing, China; 2University Of Washington, Seattle, WA, United States; 3University of Washington, Seattle, WA, United States

The Extended Graphical Model (EGM) has the ability to acquire accurate pharmacokinetic parameters (contrast transfer constant: Ktrans) using a shorter scan time than the widely used modified Kety/Tofts model in dynamic contrast enhanced (DCE) MRI of carotid atherosclerotic plaque. However, in the area of oncology, where DCE MRI and pharmacokinetic modeling are widely used in clinical research, the capability of the EGM has not been investigated. In this study, we sought to evaluate the EGM in breast imaging for use with a novel hybrid DCE MRI that provides separate high spatial and high temporal resolution datasets with full bilateral coverage.

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Keywords

accurate acquisition acquisitions agreement analyzed approved arterial assumed better bilateral biology board breast cancer capability carotid channel chemotherapy china class clinical closest coil comparing considering constant contrast correlation cover coverage curve custom datasets diagnosis duration dynamic dynamics elliptical enhanced enhancement equation estimation estimations evaluate evaluation examples excellent extended extracellular finally fitting flush flux full fully function funding generated graphical greater half hand hybrid included incorporated indicating informed injection institutional inter interleaved investigated keyhole kinetic kinetics least linear linearized long manually maps materials maximal medicine model modeling models modified monitor necessary novel oncology ongoing paired parallel partial partridge physics physiological pixel pixels plaque plasma post previous produce program protocol proven quantitative reconstructed reduce reducing reported resolution respectively review rough rows saline sampling scanner selected sense separate shorter simulation slices space spatial springer square stable subjects suggesting supported suppression systems table temporal thrive trans transfer treatment truth tumors useful validated vessel volume widely