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Abstract #3058

Measurement of Rat Brain Tumor Kinetics Using an Intravascular Mr Contrast Agent and DCE-T1 Nested Model Selection

Wilson B. Chwang1, Rajan Jain1, 2, Siamak P. Nejad-Davarani3, 4, A.S.M. Iskander1, Ashley VanSlooten5, Lonni Schultz5, James R. Ewing3, 6, Ali S. Arbab1, 7, Hassan Bagher-Ebadian3, 6

1Department of Radiology, Henry Ford Hospital, Detroit, MI, United States; 2Department of Neurosurgery, Henry Ford Hospital, Detroit, MI, United States; 3Department of Neurology, Henry Ford Hospital, Detroit, MI, United States; 4Department of Biomedical Engineering, University of Michigan, Ann Artbor, MI, United States; 5Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, United States; 6Department of Physics, Oakland University, Rochester Hills, MI, United States; 7Department of Radiology, Wayne State University, Detroit, MI, United States

The purpose of this study was to investigate parameters of vascular physiology such as vp, Ktrans, and ve in a rat glioma model using two different contrast agents, an intravascular or blood pool agent (gadofosveset) and an extravascular agent (gadopentetate dimeglumine, Gd-DTPA) using DCE T1 nested model selection. We found that Ktrans was significantly lower using gadofosveset compared to Gd-DTPA, while vp and ve measures were not statistically different. But more importantly these parameters were measured with high agreement using DCE T1 NMS, demonstrating the stability of nested model selection in DCE-MRI and its importance for assessing the tumor microenvironment.

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Keywords

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