Meeting Banner
Abstract #3060

Improving the Consistency in Permeability Measurement with DCE-MRI for Longitudinal Follow-Up of Brain Metastatic Tumors

Yi-Ying Wu1, Chen-Hao Wu1, 2, Chih-Ming Chiang1, Clayton Chi-Chang Chen1, 3, Jyh-Wen Chai1, 4

1Department of Radiology, Taichung Veterans General Hospital, Taichung City, Taiwan (R.O.C), Taiwan; 2Institute of Biomedical Engineering, National Taiwan University, Taipei City, Taiwan(R.O.C.), Taiwan; 3Department of Biomedical Engineering, Hung Kuang University, Taichung City, Taiwan (R.O.C.), Taiwan; 4College of Medicine, China Medical University, Taichung City, Taiwan (R.O.C), Taiwan

Venous output function (VOF) from the larger and straighter superior sagittal sinus, with similar shape of the concentration time curves as AIF, has shown the effectiveness in permeability measurements of brain neoplasms. However, there are still some errors from VOF that may influence the quantification of tissue permeability. The aim of this study is to investigate the clinical applicability of permeability measurement with DCE-MRI, by using a combination of the scaled AIF with VOF and the normalization to the plasma volume of the adjacent white matter, to estimate Ktrans of brain metastatic lesions in the longitudinal follow-up.

Abstract PDF Presentation Video

Keywords

according activity addition adjacent although analyzed applicability applicable applied applying arterial artery automatic available better biomedical blood brain called carotid cerebral china city clinical close coefficients college combination commercial comparing compute concentration consistency contouring contrast correlation curves determine determining deviation disease dynamic ease engineering enhanced entering errors feeding finally flow flowing flush function general guiding hung ideally improved improving included influence initially injected input internal interval larger lesion longitudinal major manifestations manually maps matrix measure measured medical medicine metastatic middle mild ming model modeling much national normalization occurred often operator output pair partial particularly patient peak permeability picked plasma post potentially preliminary procedures progression quantification radiology randomly real reasons regression relatively repeatedly reproducibility resolution saline scaled selected sensitivity sets shape significantly sinus slices software sources speed status still straighter strategies superior system table technology tissue tortuous treatment tumor tumors twelve useful variability variation various venous vessel vessels veterans volume week white