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Abstract #1388

The Impact of Chronic Exercise on Cardiac Function in PEPCK-Cmus Mice Characterized by DENSE MRI

Yuchi Liu1, Xunbai Mei1, Martin W. Zhu2, Saul Flores3, Parvin Hakimi4, Richard Hanson4, Michiko Watanabe3, Xin Yu1

1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States; 2Hawken School, Gates Mills, OH, United States; 3Department of Pediatrics, Case Western Reserve University, Cleveland, OH, United States; 4Department of Biochemistry, Case Western Reserve University, Cleveland, OH, United States

This study aimed to analyze the cardiac structure and anatomy of physically energetic PEPCK-Cmus mice, and to evaluate the efficacy of using PEPCK mouse as an animal model of exercised-induced physiological hypertrophy. Multiphase displacement-encoding with stimulated-echo technique was used to obtain in vivo measurements of cardiac anatomy and to quantify two-dimensional left ventricular myocardial wall motion.

Keywords

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