Meeting Banner
Abstract #1356

4D Flow-Sensitive MRI Pulmonary Artery Pulse Wave Velocity in Pulmonary Arterial Hypertension

Christopher J. Franois1, Alejandro Roldn-Alzate1, Andrew L. Wentland1, Heidi B. Kellihan2, Naomi C. Chesler3, Oliver Wieben1, 4

1Radiology, University of Wisconsin, Madison, WI, United States; 2Veterinary Medicine, University of Wisconsin, Madison, WI, United States; 3Biomedical Engineering, University of Wisconsin, Madison, WI, United States; 4Medical Physics, University of Wisconsin, Madison, WI, United States

4D flow-sensitive MRI was used to calculate pulmonary artery pulse wave velocity (PWV) in a canine model of acute thromboembolic pulmonary arterial hypertension (PAH). PWV significantly increased with PAH and was strongly correlated with mean pulmonary arterial pressure.

Keywords

acquisition acquisitions acute aims anesthesia animal approval arterial arteries artery assess assessed assessing atrium audience balanced beads beagles biomedical calculating calculation calculations canine cardiopulmonary centerline cine clinical coefficient complex compliance contrast correlate correlated correlation correlations curves dashed dataset demonstration depending described determined deviation diagnostics discovery distance engineering entirely expected extending feasibility female filter five flow foot frames function gating healthy heart human hypertension indicating induced induction injecting invasive isotropic knowledge known lack linear location maintained measure measured medical medicine micro model noninvasive offers oliver paired physics physiology placed post preservation pressure previous previously prior processing projection propagates pulmonary pulse quantified radial radiology readout reconstructed reconstruction regression rendered reported resolution respectively retrospective sensitive sharing significantly spatial stiffness strong student studies subjects summarized summary supported system systolic table target temporal tool unexpected upon upstroke vastly velocity vessels veterinary view volume wave weakly whole