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Abstract #1031

GM and WM Changes Correlation with Duration in MSA-P: Comparison with DTI Changes

Bo Hou1, Han Wang2, Hui You1, Bo Jiang1, Feng Feng1

1Department of Radiology, Peking Union Medical College Hospital, Beijing, China; 2Department of Neurology, Peking Union Medical College Hospital, Beijing, China

For a MSA-P group and a control group, VBM, VBM regression with disease duration, and voxel-based analysis of DTI were performed, to compare the differences between the three methods in revealing the brain changes of the MSA patients.Finally,the results showed that DTI is more sensitive to brain changes in MSA-P, and could reveal larger area of abnormality. Also, DTI changes matched well with GM and WM lost revealed by VBM and VBM regression with duration,which meant that DTI could predict early brain changes in MSA-P.

Keywords

abnormalities abnormality according actual ahead anisotropy anterior applied array atrophy axial basal bilateral bilaterally bottom brain calculating capsule cerebellar cerebral channel china coil college concentration concentrations consensus consistent controls correlating correlation cortical creating criteria customized decrease demonstrating detects diagnosis diffusion diffusivity dimensional disease duration early egger encoding excite extensive fast former forms fractional frontal ganglia generate gradient gradients gray handed head healthy help hemispheres histological hospital identify illustration in vivo inferior insular internal involved involvement known lobe lobes longitudinal loss maps matrix medical months motor negative neurology normalization occipital olives parietal particularly patients pons potential predict previous probable procedure process processed progression radiology rare recruited regression respectively reveal revealed scanner sensitive sensitivity several severe severely similarities slice spoiled statement statistical stem structural studies subjects system template temporal tensor thought topographic trend twenty uncorrected union variant verify white whole women years