Meeting Banner
Abstract #1030

Dysfunction of the Default Mode Network in Early ParkinsonS Disease: A Resting State fMRI Study

Massimo Filippi1, Federica Agosta1, Francesca Caso1, Alberto Inuggi1, Aleksandra Tomic2, Iva Stankovic2, Elisa Canu1, Igor Petrovic2, Vladimir S. Kostic2

1Neuroimaging Research Unit, Institute of Experimental Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, MI, Italy; 2Clinic of Neurology, Faculty of Medicine, University of Belgrade, Belgrade, Yugoslavia

We investigated the integrity of resting-state Default Mode Network (DMN) connectivity in patients with early Parkinsons disease (PD) and no cognitive impairment. We observed in PD patients an increased connectivity within the DMN structures including the superior and middle temporal gyri, hippocampi, parahippocampal cortex, precuneus, posterior, middle and anterior cingulate cortices compared to healthy controls bilaterally. This pattern could represent a compensatory mechanism or it could be due to a reduced thalamic outflow to the prefrontal cortex with the impairment of input/output information flows from and to this area and other DMN cortices

Abstract PDF

Keywords

abnormal according analyzed anterior arch basal bilaterally brain characterized circuit clinic clinical clinically cognitive color compensatory connectivity controls convention conversely coronal corrected correlates cortex cortices deactivation decreased default demented dementia denotes depletion disease dopamine dysfunction early enrolled experimental explanations faculty findings flows free functional functions ganglia hand healthy impairment impairments input institute integrity investigate leads manifestations maps mechanism medicine melodic middle might mild mode model modulation network networks neural neurological neurology objective outflow output patients posterior precedes prior recent reduced relevant represent resting reveal revealed salute scientific score scores secondary sections stage structures superior system tasks temporal unit vita