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Abstract #1003

Establishing MRI Phase, Abnormal MRI Phase, and Volume Behavior in the Subcortical Deep Gray Matter of Healthy Individuals

Jesper Hagemeier1, Michael G. Dwyer1, Niels P. Bergsland1, Ferdinand Schweser2, Christopher R. no1, Mari Heininen-Brown1, Deepa P. Ramasamy1, Ellen Carl1, Cheryl Kennedy1, Mariya Cherneva1, Rebecca Melia1, Paul Polak1, Andreas Deistung3, Jrgen R. Reichenbach2, Robert Zivadinov1

1Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, Buffalo, NY, United States; 2Medical Physics Group, Institute of Diagnostic and Interventional Radiology I, Jena University Hospital, Jena, Germany; 3Medical Physics Group, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany

Brain iron levels have been shown to increase with age, and to be higher in age-related neurodegenerative disorders. To fully understand the pathology of increased iron concentration in neurodegenerative disorders, it is important to take a step back and investigate aging in healthy individuals. In the present work, we show strong associations between deep gray matter mean phase measures acquired using susceptibility-weighted imaging (SWI), indicative of increased iron levels, and age in healthy individuals. This relationship is non-linear, with the highest overall iron concentrations observed in middle-age, after which levels rebound. Iron content of tissues with very high iron levels is linearly related to age. A strong association is also observed with brain atrophy.

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Keywords

abnormal addition adjusted advanced aging applying assess assessing association atrophy audience behavior blue bottom brain brown buffalo carried cohort coincidentally compensated concentration concentrations concerns connection considering content control correlated curve decades decreased deep deposition described designate detected determined diagnostic disease disorders domain dots elderly especially established establishing estimation evaluate even extent females field filtered findings flow furthermore gender general gradient gray greater gross healthy hemisphere hemispheric hospital human in vivo increasing indicative individuals institute intricately inverse investigated iron known late likely linear linearly local lowest males measure measures medical middle monitoring moreover negative neurology normalized nucleus occur overall paramagnetic pathology physics population possibly post previous proposed quadratic questions radians radiology recently reduction regression related relationship relationships remaining remains reported researchers reversal sample scanned scanner sclerosis separate several significantly strong structure structures studies subjects substances suggesting susceptibility tackle target thalamus though tissue tissues tool trend triangles unclear useful volume volumes whether window wise years