Meeting Banner
Abstract #1002

A Study of Corpus Callosum Size and Shape in Early Alzheimers Disease

Babak A. Ardekani1

1Center for Advanced Brain Imaging, The Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, United States

Structural images from the OASIS brain MRI database were used to study the corpus callosum size, characterized by its mid-sagittal cross-sectional area (CCA), and shape, characterized by its circularity (CIR) in early Alzheimers disease (AD). The CCA and CIR were compared in 98 normal controls subjects, 70 patients with very mild AD, and 28 patients with mild AD. The CIR was significantly different between the two patients groups, while CCA differences were not statistically significant. The results suggest that CIR may be a more sensitive marker than CCA for monitoring the progression of AD.

Keywords

access adjusted advanced aged aligned allow almost alongside analyzed anterior appears arbitrary arrest ascertain atlas atrophic atrophy automated automatic available better brain bring bundle capacity cerebral circularity classified clinical clinically clock close concerned connecting controls corpus corrected covariance covariates cross database decrease decreases defined deformation dementia dependent descriptive detected diagnosed diagnostic disability disease disorders distinguishing efficacy entire error evaluating examine examined extensively factorial females fiber finally fixed fully general head hemispheres hypothesis hypothesized implementation independently indicates integration inter landmarks larger largest lead linear locate located marginal matrix measure measuring mild minute model oasis objective open original pairwise patients perimeter planned post posterior priori process progression projects psychiatric publicly rage rating rectangular reduced reflects registration related relationships roll scale scaling scanner search segmentation segmentations sensitive serial series severity shape side significance slice sliced software speed statistical statistically structural studies subjects takes toolbox treatments true variable various vision volume volumes windows workstation zero