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Abstract #1004

Systemic Inflammation in Non-Demented Elderly Human Subjects Is Associated with Altered Diffusion Characteristics of Brain White Matter

Giorgia Grisot1, Debra A. Fleischman2, Anil K. Vasireddi1, Christopher M. Bart1, Lisa L. Barnes2, David A. Bennett2, Kostantinos Arfanakis1, 2

1Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States; 2Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States

The purpose of this work was to test the hypothesis that, high levels of systemic inflammation in a community sample of non-demented elderly individuals are associated with altered diffusion characteristics of brain white matter. C-reactive protein and tumor necrosis factor-alpha were measured in serum from 97 non-demented elderly subjects (age = 85.3 5.7 years). All subjects were imaged with diffusion tensor MRI. Significant negative correlations between FA and systemic inflammation, and significant positive correlations between trace and inflammation, were detected in several white matter structures, primarily driven by higher radial diffusivity for higher inflammation levels.

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Keywords

abnormal abnormalities aging alpha altered although another assayed associations axial basis biomedical blue brain bulk characteristics classifier clusters commonly community composite considering control controlling converted corona corpus corrected correlated correlation correlations define demented dementia development diffusion diffusivity disability disease distortions distribution driven eddy education elderly exact explained explanation fact family field findings flair fractional frailty frontal fully functional genes histological hypothesis individuals inferior inflammation inflammatory integrity inversion investigation involved lesion lesions linear linked lobe longitudinal machine mainly marker markers materials matrix measure measured mechanisms medical memory middle mortality necessary necrosis negative nevertheless noise null occipital onto oxford participant participants peduncle permutations persons portion positive positively potential preparation previous previously project projected protein published radial reactive registered regression reoriented repetitions risk rush sample scores segmented serum several significantly skeleton slices smith spatial statistics structural structures subject subjects superior support systemic technology tensor tensors threshold tool trace translated uniformities vector white years younger