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Abstract #0654

in vivo Single-Scan 13C Spatiotemporally-Encoded Spectroscopic Imaging of Hyperpolarized Metabolites

Rita Schmidt1, Christoffer Laustsen2, 3, Jan Henrik Ardenkjaer-Larsen, 34, Lucio Frydman1

1Chemical Physics, Weizmann Institute of Science, Rehovot, Israel; 2The MR Research Centre, Aarhus University, Aarhus, Denmark; 3Danish Research Centre for Magnetic Resonance, Hvidovre Hospital, Hvidovre, Denmark; 4GE healthcare, Broendby, Denmark

Fast and effective scanning methods are required for the hyperpolarized [1-13C]pyruvate dynamic metabolic imaging due to the short time available before the hyperpolarized signal decays. Recent studies described the potential of single-shot spatiotemporal encoding (SPEN) principles to derive chemical shift images. SPEN acquired signal contains the spatial and spectral information at no extra cost. Sequences with 180 chirp pulses were recently shown to yield single-shot chemical shift images. The present work demonstrates the first in-vivo results using a SPEN sequence; showing [1-13C]pyruvate and the metabolic derivatives in the kidneys after hyperpolarized [1-13C]pyruvate injection to healthy rats at 4.7T.

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Keywords

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