1C-TRAIN,
Washington University in St. Louis, St. Louis, MO, United States; 2Philips
Research Europe, Hamburg, Germany
This study presents a strategy to more accurately quantify the sparse 19F signal from alpha-v-beta-3-integrin targeted perfluorocarbon nanoparticle emulsions with a 1H image-based Actual Flip Angle B1-mapping correction to the 19F and 1H images, acquired with a simultaneous dual-frequency ultra-short echo time balanced steady state free precession sequence, in an in vivo setting using a VX2 tumor model implanted into rabbits.