Meeting Banner
Abstract #4477

A Proton NMR Study of Serum and Urine in Pre and Post Nutritional Intervention in Buergers Disease

Abhinav Arun Sonkar1, shatakshi srivastava2, omprakash prajapati1, jitendra kumar kushwaha1, awanish kumar1, raja roy2

1Surgery, CSM Medical University, Lucknow, Uttar pradesh, India; 2center of biomedical magnetic resonance, SGPGI, Lucknow, Uttar pradesh, India

Proton NMR spectroscopic studies of serum of patients of Beurgers disease with simultaneous urine analysis have been performed. The detailed metabolic profile in serum demonstrated significant alterations in fatty acid metabolism and homocysteine metabolism of 16 patients suffering from Beurgers Disease. The post-nutritional intervention follow up of patients (n=5) was also investigated. Whereas, fatty acid and homocysteine metabolism showed significant alterations in serum samples of diseased patients, urinalysis did not indicate disease related variations. The post-nutritional follow up of patients showed substantial clinical improvement which correlated well with Nitric Oxide levels and NMR metabolic profile of the serum.

Keywords

absence acid acids administration afflicts aggressive ambiguity among arginine arteries assay autoimmune biomedical blood branched broadening chain classification clearly clinical coagulable collected concentration control controls correlate correlation cryogenic deficiencies delay determination determined differ diminished disease diseased diseases domain dots effective endothelial equipped evaluation excluded exponential extent extremities fatty flow foot form free frequency glutamate healthy help hyper hypo identified improvement included indicated induction initial intervention involve involvement known males metabolic metabolism mild mimicked modality multiplied multivariate must nitric normalized nutritional open oxidative oxide pain pathway patients perturbations phenomenon phenylalanine plot poor population post prior production profiling proton proven pulse radio ranging reduced reducing residual rest sample samples separation serum severe severity significance smoke source spectra spectral spectrometer spectroscopy stage stored stress subjected substantial substantially suffering suppl suppressing symptoms therapy till tone transformation treatment treatments typical tyrosine ulceration ulcers unless unsupervised urine variation vascular veins vial vitamin walking ware weeks wide width