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Abstract #4359

Rescue of LV Dysfunction in a Pig Ischemia-Reperfusion Injury Model by Human Amnion-Derived Mesenchymal Stem Cells Tracked by Manganese-Enhanced MRI

Rajesh Dash1, Ildiko Toma1, Fumiaki Ikeno1, Jennifer K. Lyons1, Shahriar Heidary1, Marie-Claude Parent1, I-Ning E. Wang1, Xiaohu Ge1, Justin Lam1, Jaehoon C

1Cardiovascular Medicine, Stanford University Medical Center, STANFORD, CA- CALIFORNIA, United States; 2Medicine / Cardiology, University of Illinois-Chicago, Chicago, IL, United States; 3Cardiac Surgery, Stanford University Medical Center; 4Electrical Engineering, Stanford University; 5Eagle Vision Pharmaceutical Corporation, Downington, PA, United States

Human Amnion-derived Mesenchymal Stem Cells (hAMSCs) were transplanted into the infarct and peri-infarct regions of a pig ischemia-reperfusion model. The hAMSC therapy improved cardiac systolic function post-MI, compared to control animals, and Cardiac MRI with Manganese-Enhanced MRI (MEMRI) was able to detect increased CNR from live populations of hAMSCs within infarct and peri-infarct zones, as confirmed by human nuclear antigen (hNA) immunostaining.

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Keywords

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