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Abstract #4358

Molecular MRI-Based Detection of an Alpha-1A Receptor Agonist Treatment for Ischemia-Induced Cardiac Apoptosis

Rajesh Dash1, Justin Lam1, Ildiko Toma1, Yongquan Gong2, Robert C. Robbins2, Paul C. Simpson3, 4, Phillip C. Yang1

1Cardiovascular Medicine, Stanford University Medical Center, San Francisco, CA, United States; 2Cardiac Surgery, Stanford University Medical Center; 3Medicine / Cardiology, UCSF Medical Center, San Francisco, CA, United States; 4Cardiology, San Francisco VA Medical Center, San Francisco, CA, United States

A novel anti-apoptotic alpha-adrenergic agonist preserves left ventricular ejection fraction in mice following myocardial infarction. This therapeutic effect is able to be detected and quantified non-invasively, using T2* signal loss assessment of an Annexin-SPIO molecular apoptosis probe.

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Keywords

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