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Abstract #4041

Noninvasive Assessment of Hepatic Stiffness in Nonalcoholic Fatty Liver Disease Using Magnetic Resonance Elastography at Multiple Frequencies

An Tang1, 2, Lucas Shanholtzer2, Nikolaus Szeverenyi2, Rohit Loomba3, Michael Peterson4, Tanya Wolfson5, Anthony C. Gamst5, Richard L. Ehman6, Claude B. Sirl

1Radiology, University of Montreal, Montreal, Qc, Canada; 2Radiology, University of California, San Diego, San Diego, CA, United States; 3Division of Gastroenterology, Hepatology, and Medicine, University of California, San Diego, San Diego, CA, United States; 4Department of Pathology, University of California, San Diego, San Diego, CA, United States; 5Biostatistics, University of California, San Diego, San Diego, CA, United States; 6Radiology, Mayo Clinic, Rochester, MN, United States

Liver stiffness was measured by magnetic resonance elastography (MRE) and compared with histology. MRE performed at 3.0 T with 1 axis and 3 axes motion sensitization at multiple frequencies showed strong correlations with fibrosis stage and a trend toward higher stiffness with increasing lobular inflammation grades in adults with NAFLD. These results confirm that MRE is useful for noninvasive assessment of fibrosis not only in a variety of chronic liver disease but also in a population of NAFLD patients.

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Keywords

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