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Abstract #3750

Multivariate Analysis on Hemispheric Asymmetry Alterations in Differentiating Mild Cognitive Impairment and Alzheimer's Disease from Healthy Aging

Xiaojing Long1, Weiqi Liao1, Chunxiang Jiang1, Bensheng Qiu1, Yang Liu1, Lijuan Zhang*1

1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China

Relevant structural variates were collectively explored for a comprehensive morphological assessment on brain hemispheric asymmetry alterations among groups of healthy aging, mild cognitive impairment (MCI) converters, and Alzheimers disease (AD). Region specific preservation, reduction or reverse of hemispheric asymmetries were found to differ among groups of MCI and AD as compared with healthy aging, which may reflect the underlying mechanisms useful for disease diagnosis, differentiation and monitoring of MCI and AD.

Keywords

academy advanced aging almost alter alteration alterations alters assessment asymmetric asymmetries asymmetry attention behavior biomedical body brain caudal cerebral characteristics china cognitive coil collectively combination comprehensive constructed contemplation control converters cortex cortical covariates curvature database decline defined derived detected developed diagnosis differentiating differentiation disappearance disappeared discovery discrepancies disease disorders distance early elderly emotion emotional encoding entire episodic evidences except explore face false featured female frontal functional gender head healthy hemisphere hemispheres hemispheric homeostasis identified impairment independent index indicates individual initiative institutes integrity introduced involving known language lateralization leftward long lost male manifested markers matched memory middle mild monitoring morphological multivariate necessary neurological occurred onset outcome patients people pole preservation processing profound progressed rather recognition reduced reduction regularization relevant republic resolution retrieval retrieved reverse reversed scanned scanner sciences shape sign significance significantly social spatial structural subject subjects superior surface surfer technology temporal trio typical useful variate variates volume white yang years young