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Abstract #3749

White Matter Changes in Primary Proggressive Aphasia: A Tract-Based Spatial Statistics Analysis

Nico D. Papinutto1, 2, Sebastiano Galantucci3, 4, Jorge Jovicich5, Maria Luisa Gorno-Tempini4

1CIMeC, University of Trento, Mattarello , TN, Italy; 2University of California San Francisco , San Francisco, CA , United States; 3Scientific Institute and University Hospital San Raffaele, Milano, MI, Italy; 4University of California San Francisco, San Francisco, CA, United States; 5CIMeC, University of Trento, Mattarello, TN, Italy

The purpose of this study was to evaluate the extent and localization of white matter (WM) damages in individuals with primary progressive aphasia (PPA) by using Tract-Based Spatial Statistics (TBSS), extending the findings of previous voxel and tract-based analyses of multi-subject Diffusion Tensor Imaging (DTI) data. WM integrity was studied by comparing three groups of patients (three major subtypes of PPA: non-fluent/agrammatic (PNFA), semantic variant (SD) and logopenic variant (LPA)) with a group of age-matched healthy controls.

Keywords

acquisition aging aligned analyses angular anisotropy anterior aphasia arbitrariness atrophy became bilaterally brain canonical carried certain channel characteristic characterized check cluster coil common components comprehension computed controls corpus corrected correction covariate critical damage damages decreasing deficits described diffusion diffusivity dyslexia eddy equipped error errors evidenced extend extent family finding findings fluent focused fractional free frontal gradient gray green head healthy hemisphere increasing individuals inferior institute integrity investigate involvement language localization longitudinal loss mainly major maps maria matched misalignment motion naming neurology normalization option parallel parietal part pathologies pathways patients patterns permutations phonological planar posterior primary progressive projected proposed quite radiation randomize recruited reduction reductions registrations remarkable repetition reported resolution scientific semantic sentence separately shot significantly since skeleton smith space spatial speech spin spontaneous spreader standardized statistical statistics strong studies subgroup subject subjects subtypes suffer superior superposed surface system target temporal tensor threshold tool tract trio useful variant variants white word yellow