Meeting Banner
Abstract #3751

Longitudinal Effects of Irradiation and Voluntary Exercise on Hippocampal Gray Matter Loss

MAGNA25Sarah Biedermann1, Johannes Fuss2, Claudia Falfn-Melgoza3, Lei Zheng3, Alexander Sartorius3, Gabi Ende1, Peter Gass2, Wolfgang Weber-Fahr3

1Neuroimaging, Central Institute of Mental Health, Mannheim, Germany; 2Animal Models in Psychiatry, Central Institute of Mental Health, Mannheim, Germany; 3Translational Imaging, Central Institute of Mental Health, Mannheim, Germany

To reveal underlying mechanisms of exercise-induced gray matter increase, mice underwent hippocampal irradiation, blocking hippocampal neurogenesis, followed by voluntary wheel-running. Voxel based morphometry was performed before and after the exercise period. Age related decreased hippocampal gray matter was seen in all mice after the treatment period. Sham irradiated running mice had higher hippocampal gray matter compared to sedentary mice and a decreased loss of hippocampal gray matter over time, whereas irradiated mice did not have higher hippocampal gray matter after exercise. These findings indicate mechanisms of neuroplasticity in exercise induced hippocampal alterations.

Abstract PDF E-Poster Video

Keywords

access additionally afterwards analyzed anesthesia animal animals applied arch assessed assigned association attempt blocked brain cages central class clear cluster coil comparing corroborated cortex creation cross cryogenic cycle dark decelerated described detected diameter earlier effectively elsewhere equipped exercise exercising extraction factorial findings five fluid free full fuss gray half health housed human humans in vivo individual induced inhibited inhibits institute intervention investigated irradiated irradiation kernel known light longitudinal loss male mechanisms mental mice model models modified moreover mouse night normalized period peter plastic plasticity priori profiles psychiatry radiated rare reduced related repeated resolution revealed rodents runner runners running sample sartorius scanned scanner sectional sedentary seem segmentation segmented several sham significantly smoothed specify step steps structural studies suggest template tissue translational treatment type uncorrected underlying volume voluntary weber weeks wheel whether white whole yellow