Meeting Banner
Abstract #3521

Evaluating Transit Time and Cerebral Blood Flow Estimates in Pulsed Arterial Spin Labeling Data Among Patients with Carotid Stenoses

Bradley J. MacIntosh1, 2, Manus J. Donahue3, Michael A. Chappell4, David E. Crane1, Peter Jezzard5

1Imaging Research, Sunnybrook Research Institute, Toronto, ONTARIO, Canada; 2Medical Biophysics, University of Toronto, Toronto, ON, Canada; 3Radiology, Vanderbilt University School of Medicine; 4Institute of Biomedical Engineering, University of Oxford; 5Clinical Neurology, University of Oxford

Arterial spin labeling can be used to study stroke and other cerebrovascular diseases. Using mutiple inflow ASL (i.e. post-label delays), it is possible to estimate cerebral blood flow (CBF) and other relevant parameters like arterial transit time (ATT). We develop a metric to determine the proportion of voxels whose ASL model fit produces significant estimates of CBF and ATT. Participants had a range of carotid artery disease of which case some went on to have a carotid endarterectomy (CEA). Fewer significant CBF voxels were detected in the hemisphere with greater stenosis and among individuals went for CEA surgery.

Abstract PDF E-Poster Video

Keywords

ability absence absolute achieved acquiring acquisition acute address alternatively among arrows arterial arteries artery assess atherosclerosis atlas background biomedical biophysics blood blue bolus bound candidates carotid cerebral channel choice clinical close coil comparing compartment conducted confidence conjunction consequently correlate crane degree delay determined disease distribution distributions double downstream duration ended engineering evaluating evaluation explored fitting flow fully future gained gradient greater head hemisphere hemispheric hypotheses hypothesized impacts improve inaccuracies indicate inflow influence institute interpretation intervals issue label labeling least likely load lobes mask median medical medicine minus model modeling neurology nine note numerous oxford parametric patients perfusion peter plotted plus post produce producing pronounced proportion prudent pulsed quality radiology reasonable receive recruited reduced registration relatively reliable representative resolution routine saturation scanner school separate separated separately severe significantly simple space spin squares stroke studies successful suggest support suppression tagging tips transit treated trend trio underwent upper warped wider wise years yellow zero