Meeting Banner
Abstract #3520

Regional Reduction in Cerebral Blood Flow in Patients with Heart Failure

Rajesh Kumar1, Mary A. Woo2, Danny JJ Wang3, Paul M. Macey2, Jennifer A. Ogren2, Gregg C. Fonarow4, Ronald M. Harper1

1Neurobiology, University of California at Los Angeles, Los Angeles, CA, United States; 2UCLA School of Nursing, University of California at Los Angeles, Los Angeles, CA, United States; 3Neurology, University of California at Los Angeles, Los Angeles, CA, United States; 4Cardiology, University of California at Los Angeles, Los Angeles, CA, United States

Heart failure (HF) patients show brain injury in autonomic, neuropsychological, and cognitive regulatory sites, possibly resulting from localized hemodynamic alterations; however, regional cerebral blood flow (CBF) activity in those areas is unknown. We used non-invasive arterial spin labeling (ASL) procedures to assess regional CBF changes in HF subjects over controls. Multiple localized brain sites in HF, including frontal, parietal, and temporal regions, basal-ganglia, limbic, brainstem, and cerebellar areas showed reduced CBF, compared to controls. Regionally reduced CBF may stem from initial injury to midline medullary raphe regulatory sites, which cascades to modify vascular supply to more-rostral and cerebellar areas.

Abstract PDF E-Poster Video

Keywords

affect analyzed anterior appeared arise arterial autonomic beds bilateral blood body brain cardiology central cerebellar cerebral characteristics cognitive collected collection condition consent continuous control corpus cortex cortices covariates damage days declines decreased deficient deficits delay difficult diffusion diminished disease distance distorted dorsal endogenous especially examine failure flow frontal function functions gender gray harper healthy heart identification included index individual inferior initial injury institute insular introduce invasive inversion issues label labeled least lobe localized making male maps mass materials matrix measures medulla memory morbidity national nature nervous neurological normalized occipital optimized package parametric parietal pathological patients peduncles perfusion physiological pixel pons poor positron posterior problems procedures processes progression pulse realigned recruited reduced reduction regional regionally related repeats scanner school segmentation severe significantly slice slices smoothed software space spin stabilized stable stem structural studies subjects supported symptoms system temporal threshold tomography treatment uncorrected unified unknown validated variation water white whole written year years