Meeting Banner
Abstract #2169

Frequency Distribution of the BOLD Signal During Resting-State and Nicotine Infusion in Mice Using a Phased-Array Cryogenic Coil at 9.4T

Joanes Grandjean1, Markus Rudin1, 2

1Institute for Biomedical Engineering, ETH and University, Zrich, Switzerland; 2Institute of Pharmacology and Toxicology, University of Zrich, Switzerland

Resting-state fMRI in mice has been limited due to small voxel-size, leading to low SNR. It would allow studying mechanisms underlying resting-state fMRI, and provide a translational platform. In this study, we measured the amplitudes of low-frequency fluctuation (ALFF) of the fMRI signal during resting-state and nicotine infusion in mice and showed the organization of ALFFs in the mouse brain. Nicotine infusion increased low frequencies in the frontal cortex, and decreased medium frequencies in the sensory/motor cortex. Analysis of the ALFFs may be used to study resting-state fMRI in mice and frequency distribution can be altered following an intervention.

Keywords

absence activation activities activity acute addiction amplitude amplitudes analyzed analyzing anatomical anesthetics animal animals array aspects associative attention attractive available bands biomedical bold bolus brain brought capture coil component components compound concept conditions considered consistent control cortex cortical cryogenic default deviation discrepancies diseased distributed distribution dorsal doses engineering evaluate expansion experimental explanation feasibility female field find fluctuation fluctuations frequencies frequency frontal gradient head human humans induced infused infusion injection injections insights institute interaction intervention known leading learning little many marker mechanistic medium mice mode moreover mostly motion motor mouse network nicotine noise nuclei nucleus organization part pathological pharmacology platform possibly posterior potential previously prior prominent providing psychiatry rather rats reach receptor recorded recording reduce reduced reduction relaxant resolution respectively response responses responsible rest resting rich rodent rodents role rows sampling selected sensory serve slice slow spin statistical stein studies suggested surface tail thalamus thereby toolbox topological topologically toxicology treatment view whereas