Meeting Banner
Abstract #2168

Longitudinal FMRI of Spontaneous Plasticity in Rats After Focal Stroke Under Alpha-Chloralose Anesthetic

Tobias C. Wood1, Denise Duricki2, Lawrence Moon2, Camilla Simmons1, Michel Mesquita1, Steven Williams1, Diana Cash1

1Department of Neuroimaging, King's College London, London, United Kingdom; 2Wolfson Centre for Age Related Diseases, King's College London

We present a longitudinal fMRI study of focal stroke recovery in adult rats under Alpha-Chloralose anesthetic using forepaw stimulation. Spontaneous plasticity was observed, confirming this protocol is suitable for use with repeated imaging experiments.

Keywords

activation activations adjusting adult aged alpha always amount analyzed anesthetic animals appeared appears artifacts assessed asymmetry automatic avoid brain careful carried cash caudal caused cerebral choice college comparable compatible conducting consistent contrast coronal cortex coupled days deficit deforming detecting developed discarded discovery diseases dominant dose drug either experimental extraction facilitating false female final focal forelimb forepaws function functional generated gradient handedness hemisphere hemispheres hence hooded impairments improved indicating individual induced journal king kingdom laboratory least leaving lesion lesioned lesions linearly lister literature longitudinal masked masks medium mirrored moon moved network neural neurological neurology obvious outside overlaid paradigm pawed persistent plasticity post postural preference prior processing produce protocol pseudo pulse random randomized rats realigned recently recorded reduces regime related repeated required resolution respectively returned robust rodent scanner sensitivity sensory serial series species spontaneous squares stimulating stimulation stroke structural studies support sustained template thresholded tolerated toolbox transactions volumes warped week weeks whose wood