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Abstract #1536

A Spatially Resolved Evaluation of Radiation Induced Metabolic Response in Normal and Malignant Liver with 3D 31P MRSI

Scott Jones1, 2, Anshuman Panda1, 2, Higinia Cardenes3, James Fletcher4, Gary Hutchins4, Ulrike Dydak1, 2

1School of Health Sciences, Purdue University, West Lafayette, IN, United States; 2Department of Radiology and Imaging Sciences,, Indiana University School of Medicine, Indianapolis, IN, United States; 3Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN, United States; 4Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States

The purpose of this study is to evaluate the diagnostic and/or prognostic value of 3D 31P MRSI to assess a spatially resolved early metabolic response to ionizing radiation in both healthy and malignant liver tissue. A 3D 31P MRSI protocol using a dual-tuned 1H/31P 8-channel phased array liver coil was used to obtain 31P metabolic information throughout the whole human liver at 3.0T. 31P MRSI data from patients with hepatocellular cancer acquired before and 24 hours after undergoing stereotactic body radiotherapy are presented and show clear differential metabolic responses to radiation between healthy and malignant tissue.

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