Meeting Banner
Abstract #1537

Identification of High Intensity Focused Ultrasound Treated Tumor Tissue Using a Multiparametric MRI Protocol and ISODATA Analysis

Stefanie J.C.G. Hectors1, Igor Jacobs1, Gustav J. Strijkers1, Klaas Nicolay1

1Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands

To advance the clinical application of HIFU treatment of malignant tumors, a time-efficient multislice multiparametric MRI protocol, consisting of quantification of T1, T2, ADC and MTR, was developed. Image clustering techniques were used to differentiate non-treated and HIFU-treated tumor tissue. Results showed that after HIFU ablation, a region emerged in which pixels were assigned to clusters identified as HIFU-treated tumor tissue. MRI parameter values in this region were significantly different from parameter values in tissue identified as non-treated tumor tissue. Furthermore, a strong correlation was observed between MRI-derived HIFU-treated tumor tissue fractions and histologically derived non-viable tumor tissue fractions.

Abstract PDF Poster PDF

Keywords

ablated ablation acoustic acquisition activity adenine advance allow apparent appeared applicability assess assigned assumed biomedical blue carcinoma cell cells clear clinical clinically clustering clusters coefficient colon combined consisted control correlate correlation cycle days defined delineate derived developed diffusion directly distance distinguished done duty efficient emerged engineering entire evaluate excised excluded fast focused fraction fractions frequency goal green grid hectors hemorrhage heterogeneous hind histological histology hypo identification identified identify importance indicates induced inoculated intense intensity inter iterative limb listed locker longitudinally look magnetization mainly malignant manually mapping marker materials medicine mice microscopy minutes model molecular organizing originating overlaid pixels planar plot post power prepared protocol quantitative rank read recurrent remaining represent representative representing represents residual respectively scanner section sections self settings significantly slice square stained status stroke strong student subcutaneously successfully supported table technology therapeutic tips tissue transducer transfer translatable treated treatment tumor tumors ultrasound undergo viable visible wait weeks white whole