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Abstract #1535

Differential Response to Radiotherapy in a Mouse Xenograft Model with Half-Field Irradiation Detected by Combined DCE and BOLD MRI

Yu-Chun Lin1, 2, Chun-Chieh Wang3, Yi-Ping Lin3, Yun-Han Lin4, Jiun-Jie Wang5

1Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Linkou, Taiwan, Taiwan; 2Department of Electrical Engineering, Chang Gung University, Taoyuan, Taiwan, Taiwan; 3Department of Radiation Oncology, Chang Gung Memorial Hospital; 4Molecular Imaging Center, Chung Gung Memorial Hospital; 5Department of Medical Imaging and Radiological Sciences, Chang Gung University

Transgenic adenocarcinoma of the mouse prostate (TRAMP)-C1 tumors were irradiated on half of the tumor. Treatment response was assessed by using DCE and BOLD MRI on the 6th day after radiotherapy. Results showed that the Giant cell formed on the irradiated portion of the tumor. The irradiated area showed increased Ktrans and reduced BOLD response to carbogen breathing as compared with those at non-irradiated area. The reduced BOLD response to carbogen is related to the decreased microvascular density, which was evidenced by immunohistochemistry.

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