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Abstract #1526

The Assessment of Cellular Packing Heterogeneity in Brain Tumors Using DSC-MRI

MAGNA25Natenael Semmineh1, C. Chad Quarles1

1Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States

The use of DSC-MRI in brain tumors is known to be influenced by contrast agent extravasation, which can result in additional extravascular T1 and T2 * effects well after the contrast agent initial bolus has passed through tissue. By separating and quantifying these T1 and T2 * effects in the period of time after the contrast agents first pass we propose that a new metric, termed the extravascular susceptibility calibration factor (Ke), can be derived and used to assess cellular packing heterogeneity. In this study we demonstrate that Ke may be used to differentiate between tumor types with varying cellular features.

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Keywords

account acquiring additional advantage agent animal animals approximated assess assessment barrier bearing blood bolus brain calibration cell cells cellular characteristics color combined compartmentalization computational compute concentration confounded consistent consistently contrast created creates critical curves density derived despite dissimilar distribution dual elevated enhance evaluate even example exhibited extracellular features field focus fraction fractions free future goal greater heterogeneity heterogeneous highly histology hypothesis idea identifying impact in vivo indicate indicates indicating individualized initial institute intact interpretation inverse kinetics known larger last leakage length linear local looking maps metric metrics micro minutes models note packing pass passage passed percent perfusion period permeability permeable perturbations phys post potentially previous previously proper proposed quantifying rats reasonable recovery reflect reflecting related relates relationship reliably remained representative response revealed scale separating serve simply simulations space spacing spatial specifically staining structural studies support supporting susceptibility system taken termed theoretical tissue together treatment tumor tumors twice types variations varying vessels volume yielding