Meeting Banner
Abstract #1527

Limitation of DCE-MRI in Xenograft Model Study

Septian Hartono1, Tong San Koh2, Quan Sing Ng2, Richard Ong2, Hung The Huynh2, Sidney Yu3, Sotirios Bisdas4, Laurent Martarello5, Choon Hua Thng2

1Nanyang Technological University, Singapore, Singapore; 2National Cancer Centre, Singapore, Singapore; 3Singapore General Hospital, Singapore; 4Eberhard Karls University, Tbingen, Germany; 5F. Hoffmann-La Roche, Switzerland

DCE-MRI has been used extensively in preclinical and clinical trials as a biomarker of drug effect. It is commonly assumed that a decrease in blood volume and blood flow is related to drug effect. This study examines the pitfall of such an assumption and illustrates decrease in perfused blood volume in untreated tumor as derived by DCE-MRI

Keywords

according although animals anti antibody aorta appreciated assumed assumption avoid best beyond bingen biological blood blue bottom cancer carcinoma care carefully characterization clinical commonly confounding contrast control controls course days decrease derived design designs determine displayed done dose dosing drop dropped dropping drug dynamic enhancement especially every examines example experiment experimental extensively five flow fluid general graph grows guide hand hospital human hung illustrates implantation implanted included increasing individual injected interpretation interstitial laboratory limitation maintained male manually materials matrix measured mice model mouse must national occur omitted outlined overall particular perfused pitfall plot plots possibly postulate pressure presumably processes processing proportions reach reading related remained require resolution respective responsible scanner sets sham sharp shut sing slices stained staining studies subsequently sustained switching tail technological temporal terminal tong treated trend trends trials tumor untreated vein vessels vibe volume weeks