Meeting Banner
Abstract #1225

Highly Accelerated in vivo Measurement of Local Pulse Wave Velocity in Mice Using a K-T BLAST QA-Method

Volker Herold1, Thomas Kampf1, Alexander Gotschy1, Felix Breuer2, Eberhard Rommel1, Wolfgang Rudolf Bauer3, Peter Michael Jakob1

1Experimental Physics 5, University of Wrzburg, Wrzburg, Bavaria, Germany; 2Research Center for Magnetic Resonance Bavaria; 3Medizinische Universittsklinik, University of Wrzburg

Local elastic properties of the murine arteries such as the pulse-wave-velocity (PWV) can be calculated using PC-MRI to quantify blood-flow (Q) and cross-sectional area changes (A) (QA-method). To calculate the PWV the measured Q and A pulses have to undergo a frequency low pass filtering step. Moreover, a short total measurement time is of paramount interest, in particular with varying cardiac cycles. We present a method which substitutes temporal low pass filtering by temporal undersampled data acquisition followed by a k-t BLAST reconstruction with the benefit of an almost 10 fold acceleration of data acquisition without compromising the PWV calculation.

Abstract PDF

Keywords

abdominal accelerated acceleration according accuracy acquisition acting adjusting allows almost anesthetized animal aorta aortic applied applying averaging benefit blast blood calculation cardiac cine compliance compromising constant course cross cycle dataset described distribution early elastic elasticity enabling encoding evaluating evaluation examine examining experimental extracted filter filtering filters final flash flow fold folded frequency fully gating gradient great highly homebuilt human identical in vivo indicates inhalation knowing lattice like limited local locations measure measured mechanical mice mimic months need noise originally paramount pass pattern perpendicular peter physics plot plots post processing properties pulse pulses quantify reconstructed reconstruction reduced reduction regulates resolution resonator respiratory reveals sampled sampling scheme sectional sets short simultaneously slice slope space spatially spectrometer stability steps strength studies substitutes supplemented supported suppression systolic temporal training transferring triggering undergo unfolded velocity vessel vessels volume vulnerability wall wave