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Abstract #0961

Non-Invasive Evaluation of Tau Targeted Immunotherapy: A Tract-Tracing Bolus MEMRI Study

Benjamin Winthrop Little1, 2, Umer Khan2, Hameetha Rajamohamedsait1, Lindsay K. Hill2, Leslie Pendery2, Dung Minh Hoang2, Einar M. Sigurdsson1, 3, Youssef Z. Wadghiri2

1Physiology & Neuroscience, New York University School of Medicine, New York, United States; 2Radiology, New York University School of Medicine, New York, United States; 3Psychiatry, New York University School of Medicine, New York, United States

 

Keywords

abnormally acquisition aggregates aggregation aimed allowed alone alternatively analyzed animal animals arising assess association automatic bolus brain cell chem clearance coil commonly comprised consisting console contrast control controls correlate cortex course cross currently days decrease defined dementia described detect determination disease disturbance dung enable enabled evaluation examination experiment findings fitted fitting focusing formula function furthermore gradient grant hill home homozygous horizontal house identical improving in vivo incoherent individual injected integrity intensity interfaced invasive khan layer length lesions lewis little longitudinal made magnet manganese matrix maximal medicine mice microscopic minimal mitigate model monitoring months mouse mutant neuronal normalize normalized nostril often pathology peak physiology pons posterior presence previous previously processed processing progressive prospect protein protocol psychiatry received registration related rigid rise risk routine school scientific semi significance simplified slope smith software statistical steady strength studies system tangle tangles targeted targeting therapies tracing tract transport treated treatment twelve twenty undergone underwent uptake utilizing week worthwhile