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Abstract #0883

Asphyxiation Versus Ventricular Fibrillation Cardiac Arrest & the Effect on Cerebral Blood Flow Using ASL-MRI.

Lesley M. Foley1, Tomas Drabek2, Jason Stezoski2, T Kevin Hitchens1, 3, Robert S. Clark2, 4, Chien Ho.1, 3, Patrick M. Kochanek2, 5

1Pittsburgh NMR Center for Biomedical Research, Carnegie Mellon University, Pittsburgh, PA, United States; 2Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, United States; 3Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, United States; 4Department of Pediatrics, Childrens Hospital of Pittsburgh, Pittsburgh, PA, United States; 5Departments of Critical Care Medicine, Pediatrics and Anesthesiology, University of Pittsburgh, Pittsburgh, PA, United States

Cardiopulmonary arrest is associated with high mortality and morbidity. In this study we examined if two different insults, namely ventricular fibrillation cardiac arrest (VFCA) and asphyxia cardiac arrest (ACA), result in different spatial and temporal patterns of cerebral blood flow (CBF), with the aim of tailoring therapies specifically to the type of insults sustained. The insults produced early transient hyperemia which was significant in the ACA model, followed by significant hypoperfusion particularly in the VFCA insult. While the mechanisms are yet to be determined, our data suggest that hypoperfusion may be an important therapeutic target particularly for resuscitation following VFCA.

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Keywords

acknowledgments adequate adult affected anesthesiology anesthetized animals applied array arrest asphyxiation assumed bicarbonate bioengineering biological biomedical blood body brain brains cardiac cardiopulmonary care carried catheters cerebral channel characteristic chest circles circulation close closed coefficient coil compressions constant continuing cortex cortical critical decrease delayed deleterious despite determined diameter disconnecting early efficiency either electrical electrodes epinephrine equipped esophageal examined experienced experiment external fibrillation flow generated global grant heart hospital hyperemia included induced infusion insert inserted institute insult insults intensities intravenous intubated know labeled labeling maintained maps materials matrix mechanical mechanically mechanisms metabolic mild model models modest morbidity mortality needed open partition patterns peaking pediatrics pixel post prevalent probe procedures produced pulse quantify rats rectal regional regulated represent representative respectively resuscitated resuscitation return returned returning sciences shielded shot since sodium spatial spatially specifically spin spontaneous studies suggest supported sustained system tailoring target temperature thalamus therapies traumatic underlying unique variable ventilated ventilation ventricular versus weeks