Meeting Banner
Abstract #0884

Longitudinally Characterization of Perfusion, Diffusion & Cerebral Vascular Reactivity in Nonhuman Primate (Baboon) Stroke

Hsiao-Ying Wey1, 2, Ghazwan M. Kroma3, Jinqi Li, 23, M Michelle Leland4, Lisa Jones4, Timothy Q. Duong, 23

1Department of Radiology, A. A. Martinos Center for Biomedical Imaging, MGH/Harvard Medical School, Charlestown, MA, United States; 2Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; 3Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; 4Department of Laboratory Animal Resources, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States

This study describes the development of a large non-human primate (baboon) stroke model (permanent and transient stroke) and the implementation of multiparametric MRI protocols to characterize the evolution of lesion volume, the perfusion-diffusion mismatch, quantitative CBF and ADC changes, and cerebral vascular reactivity. Improved understanding of the lesion evolution and perfusion-diffusion mismatch in clinically relevant model of stroke might provide important information to better guide clinical diagnosis, test novel interventions and improve treatment time windows.

Abstract PDF

Keywords

achieved acute adequately aimed anatomy animal animals annals artery aspects baboon balloon better biomedical bold brain briefly cascade catheter caused cerebral characterization characterize chronic clinical close codes coil comparing conditions decreased defined deflating depict describes determined diagnosis diffusion distinct drawing early easily effective encouraging endpoint establish euthanasia evaluate eventually evolution evolutionary explore final fisher flair grew guide health hemisphere highly hour hours human humans hyper hypo identical important indicating infarct injury integrity interventions introduced invasiveness investigate irreversible laboratory larger lead lesion longitudinally loss lost malignant maps middle might mimic minimal mismatch model models nonhuman novel occlusion opposed optimized overlap perfusion permanent plotting position positive post practice primates product progression quantitative radiology reactivity reflect relevant remained renormalization reorganization reproducible resources response rhesus rodent salvaged sample scanner school science secondary seven started stroke studies subjected subsequent substantial tank temporal territory tissues transient transported treating treatment trio unchanged understanding underwent vascular viability volume written