Meeting Banner
Abstract #0882

Restorative Strength of the Remodeled Vessels After Transient Focal Cerebral Ischemia in Rats: Evaluation with BOLD MRI

Chien-Hsiang Huang1, 2, Chiao-Chi V. Chen2, Tiing-Yee Siow2, Fu-Shan Jaw1, Chen Chang2

1Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan; 2Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

Vascular remodeling which restores oxygen and nutrient supply to the affected tissues improves the prognosis of stroke patient. Evaluating restorative strength of the remodeled vessels after ischemic insult provides important information to help guide the strategy of follow-up therapy. Dilatability and oxygenation ability of the vessels are the key characteristics that determine the restorative strength. This study aimed to explore the temporal changes of dilatability and oxygenation ability after transient focal cerebral ischemia in rats using BOLD MRI.

Keywords

ability able acquisition affected allow alter anesthetized artery attributed became bilateral biomedical blood bold brain cancer capable cause cerebral challenges characteristics concerning consistent cortex custom decrease defense delayed delivering derived designed despite develop dilate dilation dilative distinct elevates elucidate engineering evaluation even evidence exchange fitted flow functional functionality goal gradient head heightened holder identify immense important increasing indicates indicating induces inhalant inhalants inhalation initial injured inside insights institute insult lack lesion lesioned light like magnet maps matrix mature maximal maximally maximize maximized maximizes middle minutes mixed moderate national nevertheless nose nutrient nutrients occlusion offer oxygen oxygenate oxygenated oxygenation perfusion pixel position possibly post potentially process promotes quantitative rats recovery regardless regressed regression remained remains remodeled remodeling repairing represent represented responded response responses restorative restore restored reveal shed shielding side slight strength stroke subjected subtracting supplying third tissue transient transition treatment treatments understanding utilizes varied vascular vessel vessels vision weeks whereas whether