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Abstract #0794

High Resolution Sodium MRI and Abnormal Sodium Ion Pump in the Bipolar Brain

Fernando Emilio Boada1, Vincent Lee1, Yongxian Qian1, Mary Phillips2, David Kupfer2

1Radiology and Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States; 2Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States

Regional Differences in Sodium Content between Euthymic Bipolar Subjects and Normal Controls were studied using High Resolution Sodium MRI at 7T. Results support the existence of statistically significant differences in sodium concentration in the basal ganglia but not in the average total brain concentration.

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Keywords

abnormal acquisition additional adulthood affects affine aimed already appearing approved basal basis bioengineering bipolar blood board body bottom brain built calibrated cause channel characteristic characterization coil comparable concentration concomitant conjugate considerably content contrast control corollary correlate cortex currently debilitating deep depicted deposition detailed disability disease disorder dose drug dysfunction early encoding escalation establishing evident explanations field function ganglia gradient grant gray hand home hypothesis identify implications important included includes individual institutional intensity intracellular investigation lead leading leads life limited lithium look minutes modulation monitored nature necessary normalization normalized part partitions pixel plot potential profiles projection protocol proton psych psychiatry pump radiology recalled reconstruction regimen regional registered regular regulates relationship remove resolution review sampling scanned scanner scheme selected self sense sensitivity serum severe side sodium spatially stable stark step strategy subject subjects success successful suggest supported supports taken theory threatening transformation treated treatment tuned twisted ultra untreated uptake varies volumetric whole wise