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Abstract #0793

Increased Brain Volumes and Cortical Surface Area in Adolescents and Young Adults at Increased Genetic Risk for Bipolar Affective Disorder

Rhoshel Lenroot1, 2, Pui Ka Yeung2, Gloria Roberts1, Clare McCormack1, Michael Breakspear1, 3, Melissa Green1, Andrew Frankland1, Adam Wright1, Phoebe Lau1, Florence Levy1, Herng Chan1, Dusan Hadzi-Pavlovic1, Philip Mitchell1

1University of New South Wales, Randwick, NSW, Australia; 2Neuroscience Research Australia, Randwick, NSW, Australia; 3Queensland Institute of Medical Research

Characterization of brain morphometry in individuals at elevated genetic risk for Bipolar Affective Disorder may illuminate early stages of the disorder and identify potential endophenotypes. Structural MRI images were acquired in 85 adolescents and young adults at elevated genetic risk for BPD and 84 matched control subjects. Brain volumes, cortical surface area and thickness were examined using an automated method. At-risk subjects had increased brain volumes and surface area, including regions such as the anterior cingulate and insula, but cortical thickness was not different. These finding suggest surface area may be a useful endophenotype for genetic studies of BPAD.

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Keywords

abnormalities abuse acquisition adolescents adults affective aged although analyses anatomic anatomical anterior arch artifact aspects automated available background bilateral bipolar brain characterization child chosen classified confirmed contributing contribution contributors control cortex cortical created date decreased demographics depression detailed determined development diagnosed diagnoses diagnosis diagnostic differ digs disorder either elevated examination except excluded exclusions existing extensive features findings full future genetic gray greater green handful hospitalization identify important include included inconsistent independent independently indicating individuals inspected institute international involvement isotropic larger levy literature longer longitudinal major male matched measured measures medical medication motion ongoing overall pair pairwise parent participants participating past people phoebe poor population potential preliminary previously processing proportion protocol psych psychiatric psychotropic records regarding related reported retained risk sample scanner schizophrenia segmentation sibling significantly south statistical status studies subgroup subjects subset substance suggests surface table treatment type useful validated variance variates visually volume volumes wales whether white year young younger