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Abstract #0496

Correlation of 31P MRS Metabolite Ratios & Near-Infrared Spectroscopy Measurements of the Redox State of Cytochrome Oxidase During & After Hypoxia-Ischemia in the Piglet

Alan Bainbridge1, Ilias Tachtsidis2, Stuart Faulkner3, Sonya Mahony2, David Price1, David L. Thomas4, Ernest B. Cady1, Nicola J. Robertson3, Xavier Golay4

1Medical Physics and Bioengineering, UCLH NHS Foundation Trust, London, United Kingdom; 2Medical Physics and Bioengineering, University College London, United Kingdom; 3Institute for Women's Health, UCL, United Kingdom; 4Institute of Neurology, UCL, United Kingdom

To investigate brain haemodynamic and metabolic changes during transient hypoxia-ischemia (HI) and recovery we integrated broadband near-infrared spectroscopy (NIRS to characterise the time courses the redox state of cytochrome-c-oxidase) with 31P MRS. We speculate that during recovery from HI, different populations of cells recover at different rates and that the relationships observed occur as a result of this. These recovery curves could be used to estimate the extent of permanent mitochondrial damage that occurs during HI in this model and thus the proportion of tissue amenable to salvage via therapeutic intervention post HI.

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Keywords

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