Meeting Banner
Abstract #0273

Hyperpolarized 13C Imaging of Metabolic Remodeling in a Porcine Cardiac Ischemia-Reperfusion Model

MAGNA25Angus Z. Lau1, 2, Albert P. Chen3, William Dominguez-Viqueira2, Marie A. Schroeder2, 4, Yiping Gu2, Jennifer Barry2, John Graham2, 5, Nilesh Ghugre2, Graham A. Wright1, 2, Charles H. Cunningham1, 2

1Dept. of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; 2Imaging Research, Sunnybrook Research Institute, Toronto, Ontario, Canada; 3GE Healthcare, Toronto, Ontario, Canada; 4Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom; 5Cardiology, St. Michael's Hospital, Toronto, Ontario, Canada

A dual respiratory and cardiac-gated, multi-slice, single-shot spiral frequency-specific 13C pulse sequence was used to characterize cardiac metabolic remodeling following acute myocardial infarction in vivo in a porcine ischemia-reperfusion model. We observed two distinct phenotypes, corresponding to myocardial stunning and infarction, with distinct metabolic remodeling patterns revealed by hyperpolarized 13C imaging. PDH flux was reduced following LAD occlusion, with recovery in stunned myocardium. Elevated myocardial lactate was observed in the peri-infarct region, presumably reflecting the potential viability of the myocardium in that area. This work may potentially enable a clinically feasible assessment of salvageable myocardium (the area-at-risk) in myocardial infarction.

Abstract PDF Presentation Video

Keywords

animal animals apex apparent arrow arrows axis biomedical blue breaths cardiac care cine clinically closed coil consistent contoured coverage defect delay described diastole distinct dual ejection elev elevated enabling enhanced feasible female flux fraction functional gated genetics global graham heart hearts hospital in vivo indicated indication induction infarct infarction injected injection injury interestingly investigated john kingdom lactate local medical metabolic mode model myocardial myocardium nature near occlusion occur open oxford perfusion physics pigs polarized post presumably previously production pulse rapid real receive recover recovery reduced remodeling respiratory revealed reversible risk runs scaled scanned short slices spectroscopy spiral start started studies stunned subjected substrate tool transmit tread tuned ventricle viable volume wall week whole wright