Meeting Banner
Abstract #0274

Proof of Concept Clinical Trial of Hyperpolarized C-13 Pyruvate in Patients with Prostate Cancer

Sarah J. Nelson1, 2, John Kurhanewicz3, Daniel B. Vigneron, Peder Larson, Andrea Harzstarck, Marcus Ferrone, Mark van Criekinge, Jose Chang, Robert Bok, Ilwoo Park, Galen Reed, Lucas Carvajal, Jason Crane, Jan Henrik Ardenkjaer-Larsen4, Albert Chen5, Ralph Hurd6, Liv-Ingrid Odegardstuen7, James Tropp6

1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States; 2Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States; 3University of California, San Francisco, United States; 4General Electric Healthcare, Denmark; 5General Electric Healthcare, Toronto, Canada; 6General Electric Healthcare, Fremont, CA, USA; 7General Electric Healthcare, Oslo, Norway

The first clinical trial using C-13 MR metabolic imaging has been successfully performed in patients with biopsy proven prostate cancer. In this dose escalation study 31 patients received an injection of 250mM hyperpolarized C-13 pyruvate, followed by metabolic imaging at 3T. Dynamic data showed arrival of C-13 pyruvate approximately 20 seconds after injection and demonstrated that the T1 was long enough to detect uptake and conversion to lactate for 60+ seconds. There were no dose limiting toxicities observed. The highest dose of 0.43mL/Kg gave the best lactate SNR and contrast in lactate/pyruvate for tumor relative to normal prostate.

Abstract PDF Presentation Video

Keywords

able absence acknowledge acquiring acquisition additional agent anatomic apply approval array assessment assessments automated best bilateral bioengineering biopsy blue body brain breast called cancer clean clear clearly clinical coil commonly complementary components concept conjunction continued control costs criteria days delivery design designed developed diagnosis dissolution dose doses dynamic electric elevated encoding escalation established exam examination examples feasibility fluid frequency general goes grade grants hardware help hematology highest hours important included indicated initial injected injection kidney kinetics lactate lesion limiting liver localization lowest meant median metabolic metabolism models modified monitor monitoring move much occurred occurs overall overlay park partially patient patients pharmacists polarization polarizations polarizer presence prior procedures process produced proof prostate proven quality received recent reduction reed resides response rodent room samples scanner shaded slice spatial sterile studies successfully suggest supported system take technology temporal therapeutic therapy third toxicity transformation treatment trial trials tumor tumors untreated version virtually volume week whole