Meeting Banner
Abstract #0192

Correlations Between PET & DTI Data in Newly Diagnosed GBM Patients Receiving Cediranib Scanned on a Hybrid PET/MR Scanner

Bjorn Stemkens1, 2, Summer Fakhro2, Daniel B. Chonde2, Marco C. Pinho2, Pavlina Polaskova2, Dominique L. Jennings2, Kyrre E. Emblem2, Elizabeth R. Gerstner3, Tracy T. Batchelor3, Ciprian Catana2

1Department of Biomedical Engineering, University of Technology Eindhoven, Eindhoven, Netherlands; 2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States; 3Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, United States

Diffusion tensor imaging (DTI) and positron emission tomography (PET) are both imaging techniques that are able to provide information about tumor cellularity and infiltration in the peritumoral region. The purpose is to observe their response in glioblastoma treatment with anti-angiogenic drugs. PET and DTI data are collected simultaneously and baseline measurements are compared to day one after treatment onset. Significant negative correlations were found between mean standard uptake values (SUV) and fractional anisotropy (FA) in the peritumoral region. This implies that metabolic changes correlate with white matter directional changes.

Abstract PDF Presentation Video

Keywords

abnormal abnormality administration advanced alleviates anisotropic anisotropy apart apparent apparently applied attenuation beyond biomedical boss brain cancer caused cell cells certified challenge clinically coefficient coincidence combination combined computed condition content continues coronal correlate correlated correlation correlations days decrease derived described describes designed determined diagnosed diffusion directional directionality drug edema effectiveness emblem engineering enhancing excluded expected forty fractional frame fused general glucose grant hand healthy hemisphere highlighted hospital human immediately implies increasing indicative infiltration inhibitor inside insight intravenous investigated isotropic iterations known likely magnitude maps maximization measure medical metabolism metric metrics middle might minute molecular necrosis negative newly normalization normalized observe occur onset ordinary partly patients positron presence pretreatment price quantitative radiation random rapid receiving reconstructed reflect registered related relationship resolution response scanned scanner scatter school significantly since start statistical subset subtracting suggests summer support tensor therapy tomography tracts transverse treated treatment trio tumor tumors upper uptake useful volumes water white years