Meeting Banner
Abstract #0191

In Vivo Spectroscopic Imaging of 2-Hydroxyglutarate in Human Brain Tumors at 3.0 T

Sandeep K. Ganji1, Abhishek Banerjee1, Zoltan Kovacs1, Ivan E. Dimitrov1, 2, Ralph J. DeBerardinis3, Craig M. Malloy1, Bruce Mickey4, Robert Bachoo5, Elizabeth A. Maher6, Changho Choi1

1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States; 2Philips Medical Systems, Cleveland, OH, United States; 3Pediatrics, UT Southwestern Medical Center, Dallas, TX, United States; 4Neurological Surgery, UT Southwestern Medical Center, Dallas, TX, United States; 5Neurology, UT Southwestern Medical Center, Dallas, TX, United States; 6Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States

2-hydroxyglutarate (2HG) is known to accumulate in a vast majority of low grade gliomas and secondary glioblastomas. We report in vivo spectroscopic imaging of 2HG using an optimized echo-time PRESS-based localization method at 3T in patients with gliomas. We present phantom and in vivo healthy volunteer validation data and show the elevated 2HG levels in tumor patients. Metabolite concentration maps are presented.

Abstract PDF Presentation Video

Keywords

acid advanced analyzing applied attributed bands bandwidth basis blue bounds brain brown carried carrier chem chemical chemotherapy choline complex concentration consistent constants containing corrections correspond coupled course created creating cycle dang dataset decreased detectability diagnostic displays drift efficacy elevated elevation encoding enhanced enhancing estimation extensively field filter fits flair frequency function gain give giving glutamate grade great green grid healthy house human improving in vivo include inset internal interval largest leads like magma maps measurable medical metabolite mickey minimize monitoring months multiplets mutations nature neurology numerical numerically optimized overlaid overlap overlapping parsons patient patients pattern peak pediatrics performance phantom pixel pixels post press prior production prognostic programs published pulses reduce reduced regional removed report reported residual residuals rise saturation scanned scheme selected separated sets several simulated simulations slice software southwestern spectra spectral spectroscopic spectrum spins studies subcutaneous subjects supported suppressed surgery systems thick treatment tumor tumors underwent validated view volume water width written