Meeting Banner
Abstract #0122

White Matter Microstructural Changes in Bipolar Disorder: A HARDI CSD Tractography Study

SUMMA25Louise Emsell1, 2, Alexander Leemans3, Wim Van Hecke4, 5, Camilla Langan2, Gareth J. Barker6, Peter McCarthy2, Stefan Sunaert1, Dara Cannon2, Colm McDonald2

1Radiology, KU Leuven, Leuven, Belgium; 2NUI Galway, Ireland; 3Image Sciences Institute, UMC Utrecht, Netherlands; 4University Hospital Antwerp, Belgium; 5icoMetrix, Belgium; 6Department of Neuroimaging, King's College London,Institute of Psychiatry, United Kingdom

Structural brain changes detected by diffusion tensor tractography have been reported in bipolar disorder. However the investigation of heterogeneous clinical populations and the limitations of the tensor model for tractography have resulted in contradictory findings. We used high angular resolution diffusion imaging and a constrained spherical deconvolution approach to improve tract delineation in crossing-fibre regions. We investigated anatomically defined subdivisions of the corpus callosum, cingulum and fornix in a sample of 35 prospectively confirmed euthymic bipolar 1 disorder patients and 44 healthy controls. We detected widespread reductions in fractional anisotropy and increases in diffusivity measures in patients compared to controls.

Abstract PDF Presentation Video

Keywords

able abuse aging alcohol alteration angular anisotropy anterior applied atlas axial bilateral biological bipolar brain bundle cant clarify clinical clinically college confirmed consistent consistently constrained contain control controls corpus corrected covariates created crossing dataset date deconvolution decreased deficits define density depression despite detected detection deterministic diagnosis difficult diffusion diffusivity discrepant disorder disorders dorsal emerging ends every examined exclusion extent extracted finding findings fixed focused force fractional global gradient heterogeneity hinder homogeneous human improve included institute interpretation intro king kingdom localized location loss major majority make mania mapping masks matrix measures median metrics model models modulated month motion para parietal partial patients peter portion portions post posterior potential previous prior projections psychiatric psychiatry radial rather rating reduction regulation relationships relatively reliable remains remitted reported scale sciences segments seldom slices space specificity subject subjects supports table temp tensor throughout track tracking tract tracts trait variable variables varies view volume white whole year young