Meeting Banner
Abstract #0121

Multiple Echo Diffusion Tensor Acquisition Technique (MEDITATE) Implementation on 3T Clinical Scanner

Steven Baete1, Gene Cho1, 2, Eric E. Sigmund1

1Center for Biomedical Imaging, Dept. of Radiology, NYU Langone Medical Center, New York, NY, United States; 2Sackler Institute of Graduate Biomedical Sciences, NYU School of Medicine, New York, NY, United States

This abstract describes the implementation of a rapid method to acquire a full diffusion tensor in on a clinical scanner. The method is named the 3D multiple modulation multiple echo diffusion tensor acquisition technique (MEDITATE). MEDITATE employs four rf-pulses and a pattern of diffusion gradients on three gradient axes to encode a train of 17 echoes with different diffusion weightings and directions. The resulting diffusion weighted signals can be used to estimate DTI parameters as demonstrated in a fibrous phantom. This sequence may be useful in clinical applications requiring time-sensitive acquisition of DTI parameters such as dynamical DTI in muscle.

Keywords

accelerated acknowledge acquisition additionally agreement allow amplitude analyzed anisotropy applications appropriate approximate argument asparagus available axial biological biomedical channel characteristics chem chosen clinical coil collected combinations combined computed condition considering cylindrical dataset datasets decrease decreases demonstrating dept despite diagonal differently diffusion diffusivity directivity distributed earlier echoes effective eigenvalues elements employing encodes encoding error estimation exhibit feasibility fibers field finite fitting focus fractional full funding gene generate giving gradient gradients graduate hence homogeneously horizontal idea implementation implementing in vivo included institute isolate isotropic knee lobes magnitude magnitudes many maps matrices matrix maximally measurable medical meditate minimize model muscle needed neural noise optimization optimized oriented pathways phantom phys pipe platform plot potentially principal process processed pulse pulses quality radiology relatively renal required resolution resolved rise samples sampling scanner scheme school segments skeletal song space spin stalk stalks strength studies subsequently support suppress tang tensor tenth theoretically timing tissue tubules unwanted unweighted variation view water wide