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Abstract #0123

Disrupted White-Matter Structural Networks in Attention Deficit Hyperactivity Disorder

Ni Shu1, Qingjiu Cao2, Li Sun2, Li An2, Peng Wang2, Jinhui Wang3, Mingrui Xia3, Yufeng Wang2, Yong He3

1State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University , Beijing, China; 2Institute of Mental Health, Peking University, Beijing, China; 3State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China

In this study, we used diffusion tensor imaging and graph theoretical approaches to investigate the whole-brain white-matter connectional architecture in ADHD patients. We found disrupted topological organization of whiteCmatter structural networks in ADHD patients. Both decreased and increased connections in the patients were mainly located in the frontal regions, insula and striatum structures, providing evidence for the hypothesis of abnormal fronto-striatal-insular circuitry in ADHD. Specifically, the disrupted connections in the fronto-insular component were associated with the inattention performances in patients, improving our understanding of the potential mechanisms underlying the behavior deficits in patients with ADHD.

Keywords

absolute academic adolescence adulthood alterations altered analyses angular applied approaches attention automated brain cause characteristics characterized china circuit clustering common component components connections connectivity considered constructed controls corrected correlated correlations cortex decreased deficit deficits defined definition despite details developed diffusion disorder disorders disrupted disruption distributions domains edge efficiencies efficiency evidence finally frontal functional global gong graph health healthy hyperactivity hypothesis hypothesized identify impaired impairments important improving impulsion inattention includes inferior institute insular investigate known labeling laboratory learning length lingual little lobe local located mainly males measures mechanisms medial middle negatively network networks ninety nodal node nodes normalized occipital orbital organization package pairs parietal part participants path patients people performances permutation persisting potential probabilistic probability properties providing psychiatry recently reduced regional related relationship remained republic resolution revealed scores several shortest significantly social sparsity statistical strength structural structures subject suggested symmetric symptoms tensor theoretical threshold thresholding topological trio unclear underlying understanding white whole