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Abstract #4526

Accurate Quantitative Myocardial Perfusion Using Single Cycle T1 Mapping

David Chen1, Behzad Sharif1, Debiao Li1

1Cedars Sinai Medical Center, Los Angeles, CA, United States

Quantitative myocardial perfusion MRI depends on accurate determination of the arterial input function. By calculating blood and myocardial T1 values during the first pass, CA concentration can be estimated accurately, overcoming the signal saturation problem. This method requires only a single scan which minimizes both scan time and setup time.

Keywords

accurate accurately acquisition agent allow allows amplitude approval arterial audience bandwidth black blood boluses builds calculating cardiac cause cedars clinical coil collected comparing complicates composite concentration concentrations constraint contrast converted correct corrected correction curve curves cycle datasets deconvolution delay density depends derived described determination diastolic doses drawn dual eliminates eliminating encoded error exercise expected fast favorably finding fitting flows function healthy in vivo include independent injections intensity interleaved interval investing known linear long magnetization major making manually mapping matrix measured medical minimizes model myocardial needs overcoming partial pass peak perfusion phys pixel pool position potential practical preparation problem procedure produced produces properly proposed proposes quantitative radial radially readouts reconstruction recovered reduces require researchers residual resolution respect respectively rest saturation scale scaled scaling sensing sensitivity separate setup short shot simple slice solving source space spacing started studies subjects system table taken target theoretically tissue truncation typical uncorrected underwent unfortunately unsaturated variations volume volunteers wash